Analytical Data
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基因名
KCNJ15
- Application
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别名
KCNJ15; KCNJ14; ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+ channel Kir1.3; Inward rectifier K(+ channel Kir4.2; Potassium channel. inwardly rectifying subfamily J member 15
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99712
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表达区间
1-375aa
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氨基酸序列
MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEVYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV
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分子量
66.99 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNJ15, a member of the inwardly rectifying potassium channel family, plays a crucial role in various physiological processes, including cellular excitability, potassium homeostasis, and ion transport. The gene encoding KCNJ15 is located on chromosome 21, and mutations in this gene have been associated with several health conditions, particularly related to kidney function and blood pressure regulation. Research has linked KCNJ15 to the pathogenesis of hypertension and diabetes, highlighting its importance in cardiovascular and metabolic health. Given its potential as a therapeutic target, the study of recombinant KCNJ15 protein has gained significant attention. Producing and characterizing this protein can provide insights into its structure-function relationships and facilitate the identification of therapeutic compounds that modulate its activity. Furthermore, understanding the molecular mechanisms through which KCNJ15 operates can lead to advancements in treating disorders related to potassium channel dysfunction. This research not only enriches our knowledge of ion channel biology but also opens avenues for innovative interventions in diseases linked to KCNJ15 dysregulation.
