Analytical Data
-
Gene name
KCNJ15
- Application
-
Alternative Names
KCNJ15; KCNJ14; ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+ channel Kir1.3; Inward rectifier K(+ channel Kir4.2; Potassium channel. inwardly rectifying subfamily J member 15
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q99712
-
Expression Region
1-375aa
-
AA Sequence
MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEVYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV
-
Molecular Weight
66.99 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNJ15, a member of the inwardly rectifying potassium channel family, plays a crucial role in various physiological processes, including cellular excitability, potassium homeostasis, and ion transport. The gene encoding KCNJ15 is located on chromosome 21, and mutations in this gene have been associated with several health conditions, particularly related to kidney function and blood pressure regulation. Research has linked KCNJ15 to the pathogenesis of hypertension and diabetes, highlighting its importance in cardiovascular and metabolic health. Given its potential as a therapeutic target, the study of recombinant KCNJ15 protein has gained significant attention. Producing and characterizing this protein can provide insights into its structure-function relationships and facilitate the identification of therapeutic compounds that modulate its activity. Furthermore, understanding the molecular mechanisms through which KCNJ15 operates can lead to advancements in treating disorders related to potassium channel dysfunction. This research not only enriches our knowledge of ion channel biology but also opens avenues for innovative interventions in diseases linked to KCNJ15 dysregulation.
