Analytical Data
-
基因名
IRF3
- Application
-
别名
IRF3;Interferon regulatory factor 3
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q14653
-
表达区间
2-427aa
-
氨基酸序列
MASMTGGQQMGRGHHHHHHENLYFQGEFGTPKPRILPWLVSQLDLGQLEG VAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDL PTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTS PDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRS PSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCP EGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLA LWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLG PFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLR ALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQG PGES
-
分子量
50 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IRF3 (Interferon Regulatory Factor 3) is a crucial transcription factor involved in the innate immune response, primarily recognizing viral infections and facilitating the production of type I interferons. Research into IRF3 and its recombinant protein has gained significant interest due to its critical role in antiviral defense mechanisms. Following the detection of viral DNA or RNA, IRF3 is activated through phosphorylation, leading to its dimerization and translocation into the nucleus, where it initiates the transcription of genes that are essential for immune responses. Dysregulation of IRF3 activity is associated with various diseases, including chronic viral infections and autoimmune disorders. Additionally, potential applications of IRF3 recombinant protein in therapeutic strategies are being explored, particularly in enhancing immune responses in vaccines and as a biomarker for disease progression. The study of IRF3, therefore, not only contributes to our understanding of the molecular mechanisms underpinning immune regulation but also opens new avenues for the development of innovative antiviral therapies and vaccines, making it a focus of ongoing biomedical research.
