Analytical Data
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基因名
KBTBD8
- Application
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别名
AU040152; FLJ57592; KBTB8_HUMAN; Kbtbd8; Kelch repeat and BTB (POZ) domain containing 8 ; Kelch repeat and BTB domain containing protein 8; Kelch repeat and BTB domain-containing protein 8; KIAA1842; MGC91215; mKIAA1842
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFY9
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表达区间
1-601aa
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氨基酸序列
MAASADLSKS SPTPNGIPSS DPASDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVILTEANV QALFTAASIF QIPSIQDQCA KYMISHLDPQ NSIGVFIFAD HYGHQELGDR SKEYIRKKFL CVTKEQEFLQ LTKDQLISIL DSDDLNVDRE EHVYESIIRW FEHEQNEREV HLPEIFAKCI RFPLMEDTFI EKIPPQFAQA IAKSCVEKGP SNTNGCTQRL GMTASEMIIC FDAAHKHSGK KQTVPCLDIV TGRVFKLCKP PNDLREVGIL VSPDNDIYIA GGYRPSSSEV SIDHKAENDF WMYDHSTNRW LSKPSLLRAR IGCKLVYCCG KMYAIGGRVY EGDGRNSLKS VECYDSRENC WTTVCAMPVA MEFHNAVEYK EKIYVLQGEF FLFYEPQKDY WGFLTPMTVP RIQGLAAVYK DSIYYIAGTC GNHQRMFTVE AYDIELNKWT RKKDFPCDQS INPYLKLVLF QNKLHLFVRA TQVTVEEHVF RTSRKNSLYQ YDDIADQWMK VYETPDRLWD LGRHFECAVA KLYPQCLQKV L
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分子量
68.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
KBTBD8 is a member of the Kelch repeat and BTB (Bric-à-brac, Tramtrack, and Broad-complex) domain-containing protein family, which plays crucial roles in various cellular processes, including signal transduction, protein degradation, and cytoskeleton organization. Recent studies have highlighted KBTBD8's involvement in the regulation of the ubiquitin-proteasome system, a key pathway for protein degradation and quality control within cells. Dysregulation of this pathway is implicated in various diseases, including cancer and neurodegenerative disorders. Researchers aim to explore the functional mechanisms of KBTBD8 by creating recombinant protein forms that can be utilized in biochemical assays to elucidate its interactions with substrate proteins and components of the ubiquitin pathway. Understanding KBTBD8’s structure and function may provide insights into its role in cellular homeostasis and its potential as a therapeutic target. Given its emerging significance, further investigation into KBTBD8 may reveal novel therapeutic strategies for diseases related to its dysregulation, emphasizing the need for detailed structural and functional characterizations of this protein.
