Analytical Data
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Gene name
TCN1
- Application
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Alternative Names
TCN1；TC1；Transcobalamin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20061
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Expression Region
24-433aa
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AA Sequence
EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQ KMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLE NKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPE NKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKS LVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVL TEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPI TVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIF GFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNG ENLEVRWSKY
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Molecular Weight
62 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCN1 (Tetratricopeptide Repeat Protein 1) is a protein that has garnered attention in the field of molecular biology and biochemistry due to its unique structural motifs and potential functional roles. As a member of the tetratricopeptide repeat (TPR) family, TCN1 is characterized by a repetitive sequence that facilitates protein-protein interactions, which are critical in various cellular processes including transcription regulation, protein folding, and signaling pathways. The study of TCN1 recombinant protein has been motivated by its involvement in essential biological functions and its potential implications in disease mechanisms, particularly in cancers and neurodegenerative disorders. By producing recombinant TCN1, researchers aim to elucidate its biochemical properties, optimal folding conditions, and interactions with other proteins, thereby contributing valuable insights into its functional roles in the cell. Additionally, understanding the dynamics of TCN1 may pave the way for the development of therapeutic strategies targeting its pathways. The ongoing research into TCN1's structure and function reinforces the importance of this protein in both basic and applied sciences, highlighting its potential as a biomarker and as a therapeutic target for various diseases.
