Cat: PA1000-1584

Recombinant Human IL-15 Protein,His

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Analytical Data

  • 基因名

    IL-15

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    IL15;Interleukin-15

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P40933

  • 表达区间

    49-162aa

  • 氨基酸序列

    NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVI SLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFL QSFVHIVQMFINTS

  • 分子量

    13 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Interleukin-15 (IL-15) is a pivotal cytokine involved in the regulation of immune responses, particularly in the proliferation and activation of natural killer (NK) cells and CD8+ T cells. Its unique role in enhancing immune responses has garnered significant interest in the field of immunotherapy, especially for cancer treatment and infectious diseases. Unlike other cytokines, IL-15 can be produced by various cell types and possesses a mechanism of action that allows it to be presented on the surface of cells, making it a crucial factor in maintaining memory T cells and supporting the survival of lymphocytes. Research on recombinant IL-15 protein has revealed its potential not only in boosting immune cell function but also in improving the efficacy of vaccines and therapeutic protocols. This exploration has led to advances in designing IL-15-based therapies, including its use in combination with monoclonal antibodies and other immunotherapeutic agents. Furthermore, understanding the molecular mechanisms underlying IL-15 signaling has opened new avenues for targeted therapies aimed at modulating immune responses in cancer and other diseases. Ongoing studies are focused on optimizing delivery methods, understanding dosage effects, and minimizing potential side effects, while preclinical and clinical trials are assessing the safety, tolerability, and effectiveness of recombinant IL-15 in various therapeutic contexts. The compelling properties of IL-15 make it a promising candidate for enhancing immunotherapeutic strategies, emphasizing the need for continued investigation into its therapeutic applications.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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