Analytical Data
-
Gene name
KAL
- Application
-
Alternative Names
KAL；KLK3；Plasma kallikrein
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P23352
-
Expression Region
384-680aa
-
AA Sequence
RLKSAKVSLH FTSTHATNNK EQLVKTRKGG IQTQLPFQRR RPTRPLEVGA PFYQDGQLQV KVYWKKTEDP TVNRYHVRWF PEACAHNRTT GSEASSGMTH ENYIILQDLS FSCKYKVTVQ PIRPKSHSKA EAVFFTTPPC SALKGKSHKP VGCLGEAGHV LSKVLAKPEN LSASFIVQDV NITGHFSWKM AKANLYQPMT GFQVTWAEVT TESRQNSLPN SIISQSQILP SDHYVLTVPN LRPSTLYRLE VQVLTPGGEG PATIKTFRTP ELPPSSAHRS HLKHRHPHHY KPSPERY
-
Molecular Weight
36 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KAL, or Kallmann syndrome protein, is a crucial component in the understanding of various genetic and developmental disorders. It primarily encodes a protein involved in the migration of gonadotropin-releasing hormone (GnRH) neurons during embryonic development. Mutations in the KAL gene are linked to Kallmann syndrome, a genetic condition characterized by delayed or absent puberty and a reduced sense of smell due to the improper formation and function of the reproductive system. Research into KAL recombinant proteins aims to elucidate the mechanisms of GnRH neuronal migration and function, providing insights into the pathology of Kallmann syndrome and related disorders. Additionally, studying the structure and function of the KAL protein may open new avenues for therapeutic interventions and enhance our understanding of reproductive endocrinology. Understanding the role of KAL can also shed light on broader neurodevelopmental processes, as similar mechanisms may be involved in other neurological and hormonal systems. Thus, the investigation of KAL recombinant proteins not only holds potential for addressing specific genetic disorders but also contributes to the overall knowledge of human development and neurobiology.
