Cat: PA2000-8490

Recombinant Human INTS12 Protein,GST

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Analytical Data

  • Gene name

    INTS12

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    INTS12; PHF22; SBBI22; Integrator complex subunit 12; Int12; PHD finger protein 22

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q96CB8

  • Expression Region

    1-462aa

  • AA Sequence

    MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM VKKKAAQKKL KK

  • Molecular Weight

    48.8 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

INTS12, a member of the Integrator complex, plays a crucial role in the regulation of gene expression, particularly in the processing of non-coding RNAs and the maturation of mRNA. Research into INTS12 has gained prominence due to its involvement in various cellular processes, including transcriptional regulation and RNA splicing. Dysregulation of INTS12 has been implicated in several diseases, including cancer, making it a significant target for therapeutic interventions. The study of recombinant INTS12 protein is essential for elucidating its biochemical properties and functional mechanisms within the Integrator complex. By producing INTS12 as a recombinant protein, researchers can investigate its interactions with other proteins and RNA, thus providing insights into its role in RNA processing and gene expression regulation. Furthermore, understanding INTS12's structure and function can help identify potential inhibitors or modulators that could serve as novel therapeutic agents for treating conditions associated with its dysregulation. Overall, the ongoing research on recombinant INTS12 protein aims to unravel its contributions to cellular homeostasis and its potential as a biomarker or therapeutic target in various diseases.

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