Analytical Data
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Gene name
HNRNPA1
- Application
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Alternative Names
HNRNPA1;HNRPA1;Heterogeneous nuclear ribonucleoProtein A1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P09651-2
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Expression Region
1-320aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSKSESP KEPEQLRKLF IGGLSFETTD ESLRSHFEQW GTLTDCVVMR DPNTKRSRGF GFVTYATVEE VDAAMNARPH KVDGRVVEPK RAVSREDSQR PGAHLTVKKI FVGGIKEDTE EHHLRDYFEQ YGKIEVIEIM TDRGSGKKRG FAFVTFDDHD SVDKIVIQKY HTVNGHNCEV RKALSKQEMA SASSSQRGRS GSGNFGGGRG GGFGGNDNFG RGGNFSGRGG FGGSRGGGGY GGSGDGYNGF GNDGSNFGGG GSYNDFGNYN NQSSNFGPMK GGNFGGRSSG PYGGGGQYFA KPRNQGGYGG SSSSSSYGSG RRF
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is a crucial protein involved in various cellular processes, including RNA splicing, transport, and stability. It plays a significant role in the regulation of gene expression by binding to pre-mRNA and influencing the maturation of messenger RNA (mRNA) in the nucleus. Abnormalities in HNRNPA1 have been linked to several pathological conditions, including neurodegenerative diseases, cancers, and myopathies. Given its importance in post-transcriptional regulation, researchers have increasingly focused on the recombinant expression of HNRNPA1 to understand its structure-function relationships, protein-protein interactions, and the molecular mechanisms underlying its involvement in disease. The recombinant protein can be utilized for various biochemical and biophysical assays, providing insights into its binding affinities, conformational dynamics, and interaction with nucleic acids and other proteins. Furthermore, studying HNRNPA1 in recombinant form allows for the development of potential therapeutic approaches aimed at correcting its dysfunctions. Overall, HNRNPA1 remains a key subject of study in molecular biology and biomedical research, contributing to our understanding of RNA processing and the intricate networks governing cellular function and disease progression.
