Cat: PA2000-8434

Recombinant Human IGHM Protein,GST

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Analytical Data

  • Gene name

    IGHM

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    IGHMImmunoglobulin heavy constant mu; Ig mu chain C region; Ig mu chain C region BOT; Ig mu chain C region GAL; Ig mu chain C region OU

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P01871

  • Expression Region

    1-489aa

  • AA Sequence

    MNYYWGQRTLVTVSSGSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTEGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK

  • Molecular Weight

    80.1 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

Immunoglobulin heavy chain mu (IGHM) is a critical component of the immune system, primarily associated with the initial antibody response during B cell development. Research into recombinant IGHM proteins has gained significant interest due to their potential application in vaccine development and therapeutic interventions. Understanding the structure and function of IGHM is essential for elucidating the mechanisms of humoral immunity, particularly how B cells differentiate and produce antibodies upon encountering pathogens. Advances in genetic engineering and protein expression systems have enabled the production of recombinant IGHM proteins, facilitating detailed studies on their biophysical properties and interactions with antigens. This research is pivotal for developing novel immunotherapeutics, including monoclonal antibodies, and for enhancing vaccine efficacy by elucidating how IGHM can influence immune responses. Furthermore, studying IGHM's role in class-switch recombination and somatic hypermutation provides insights into the adaptive immune response's complexity and diversity. As the field of immunology progresses, recombinant IGHM proteins serve not only as valuable research tools but also hold the promise for innovative treatments and diagnostic methods in combating infectious diseases and other immune-related disorders.

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