Analytical Data
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基因名
IFT52
- Application
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别名
IFT52; C20orf9; NGD5; CGI-53; Intraflagellar transport protein 52 homolog; Protein NGD5 homolog
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y366
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表达区间
1-437aa
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氨基酸序列
MEKELRSTILFNAYKKEIFTTNNGYKSMQKKLRSNWKIQSLKDEITSEKLNGVKLWITAGPREKFTAAEFEILKKYLDTGGDVFVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVYHKYFHPKEALVSSGVLNREISRAAGKAVPGIIDEESSGNNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLNQIDAEDPEISDYMMLPYTATLSKRNRECLQESDEIPRDFTTLFDLSIFQLDTTSFHSVIEAHEQLNVKHEPLQLIQPQFETPLPTLQPAVFPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHVFFQVVEFKKLNQEHDIDTSETAFQNNF
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分子量
76.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFT52, or Intraflagellar Transport 52, is a central component of the intraflagellar transport (IFT) machinery, essential for the biogenesis and maintenance of cilia and flagella in eukaryotic cells. Cilia and flagella play crucial roles in various cellular processes, including motility, signaling, and sensory functions. Dysfunction in IFT components like IFT52 has been linked to a range of ciliopathies—genetic disorders caused by impaired cilia function—resulting in severe developmental and health issues. This has prompted extensive research into the structure, function, and mechanisms of IFT proteins. Recent studies on IFT52 indicate that it not only plays a role in the assembly and transport of ciliary components but also interacts with various other cellular pathways, providing insights into its multifaceted biological roles. Understanding IFT52 and its interactions is vital for elucidating the mechanisms underlying ciliopathies and could potentially lead to novel therapeutic strategies for these conditions. The research on IFT52 is thus positioned at the intersection of cell biology, genetics, and medical science, highlighting its significance in both basic research and clinical applications.
