Analytical Data
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Gene name
HMGA2
- Application
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Alternative Names
HMGA2;HMGIC;High mobility group Protein HMGI-C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P52926
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Expression Region
1-109aa
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AA Sequence
MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH
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Molecular Weight
13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HMGA2 (High Mobility Group A2) is a non-histone chromosomal protein that plays a crucial role in gene expression regulation, cell proliferation, and differentiation. It has been implicated in various biological processes, including embryonic development and tumorigenesis. The study of HMGA2 is particularly important due to its association with several types of cancers, where its overexpression can contribute to malignant transformation and increased metastatic potential. Researchers have been focusing on the recombinant expression of HMGA2 to better understand its structure-function relationship and its interactions with DNA and other proteins. By producing HMGA2 as a recombinant protein, scientists can investigate its binding affinities, cellular localization, and regulatory mechanisms in a controlled environment. This research has the potential to uncover novel therapeutic targets and strategies for cancer treatment, as well as provide insights into the molecular pathways regulated by HMGA2 in normal and pathological conditions. Furthermore, studying HMGA2's role in developmental biology could lead to advances in regenerative medicine and tissue engineering. Overall, the investigation of HMGA2 recombinant proteins forms a vital part of ongoing research aimed at deciphering the complex roles of this protein in health and disease.
