Analytical Data
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基因名
ARRb2
- Application
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别名
ARRb2；ARB2；ARR2；Beta-arrestin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32121
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表达区间
1-409aa
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氨基酸序列
MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLK DRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTR LQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAF CAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHL EASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQY KCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTN LASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPH DHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMK DDDYDDQLC
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分子量
73 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARRb2 (arrhythmogenic right ventricular cardiomyopathy protein 2) is a critical protein implicated in the regulation of cardiac function and the pathophysiology of arrhythmogenic right ventricular cardiomyopathy (ARVC), a genetic heart disease characterized by ventricular arrhythmias and risk of sudden cardiac death. Research into ARRb2 has gained traction as understanding its role can elucidate the molecular mechanisms underpinning ARVC and potentially lead to targeted therapies. The protein is known to be involved in various cellular processes, including cardiac cell signaling, contractility, and apoptosis. Mutations in the ARRb2 gene have been associated with familial cases of ARVC, highlighting its significance in inherited cardiovascular conditions. Recent studies focus on the expression, structure, and function of recombinant ARRb2 proteins to better understand how specific mutations alter its properties and contribute to disease pathology. Employing advanced techniques such as molecular cloning, protein purification, and functional assays, researchers aim to dissect the contributions of ARRb2 to cardiac health and disease. Such insights not only advance our comprehension of ARVC but also pave the way for novel therapeutic strategies, enhancing patient outcomes in those affected by this debilitating condition.
