Analytical Data
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Gene name
ERG26
- Application
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Alternative Names
ERG26；H105E3；Sterol-4-alpha-carboxylate 3-dehydrogenase. decarboxylating
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Species
E.coli
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P53199
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Expression Region
1-349aa
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AA Sequence
MSKIDSVLIIGGSGFLGLHLIQQFFDINPKPDIHIFDVRDLPEKLSKQFTFNVDDIKFHKGDLTSPDDMENAINESKANVVVHCASPMHGQNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFNGQDVHNADETWPIPEVPMDAYNETKAIAEDMVLKANDPSSDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGQSKFQIGDNNNLFDWTYAGNVADAHVLAAQKLLDPKTRTAVSGETFFITNDTPTYFWALARTVWKADGHIDKHVIVLKRPVAICAGYLSEWVSKMLGKEPGLTPFRVKIVCAYRYHNIAKAKKLLGYTPRVGIEEGINKTLAWMDEGL
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Molecular Weight
46.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ERG26 is a crucial enzyme involved in the biosynthesis of ergosterol, a vital component of fungal cell membranes, which plays a significant role in maintaining membrane integrity and function. The study of ERG26, a member of the cytochrome P450 enzyme family, is particularly important in the context of antifungal drug development, as ergosterol is a key target for many antifungal agents used to treat fungal infections. Understanding the structure and function of ERG26 can provide insights into its mechanism of action and its regulation, which can be pivotal for designing more effective antifungal therapies. Furthermore, investigating the genetic and biochemical properties of ERG26 can aid in elucidating the pathways of ergosterol biosynthesis, which is essential not only for fungal growth but also for the development of resistance to existing antifungal medications. Enhanced knowledge of ERG26 can foster the discovery of new inhibitors that could potentially overcome resistance mechanisms, thereby improving treatment outcomes for patients with fungal infections. This research offers a promising avenue for addressing the global challenge posed by fungal diseases, particularly as emerging resistance to current antifungal drugs continues to escalate. Overall, the ongoing investigation into ERG26 and its role in fungal biology represents a strategically important area of study aimed at advancing therapeutic options and contributing to global health initiatives.
