Analytical Data
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基因名
HAAO
- Application
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别名
HAAO;3-hydroxyanthranilate 3.4-dioxygenase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46952
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表达区间
1-286aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMERRLG VRAWVKENRG SFQPPVCNKL MHQEQLKVMF IGGPNTRKDY HIEEGEEVFY QLEGDMVLRV LEQGKHRDVV IRQGEIFLLP ARVPHSPQRF ANTVGLVVER RRLETELDGL RYYVGDTMDV LFEKWFYCKD LGTQLAPIIQ EFFSSEQYRT GKPIPDQLLK EPPFPLSTRS IMEPMSLDAW LDSHHRELQA GTPLSLFGDT YETQVIAYGQ GSSEGLRQNV DVWLWQLEGS SVVTMGGRRL SLAPDDSLLV LAGTSYAWER TQGSVALSVT QDPACKKPLG
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HAAO (3-hydroxyanthranilic acid 2,3-dioxygenase) is an essential enzyme in the kynurenine pathway, which is a critical metabolic route for tryptophan catabolism. This pathway is significant due to its implications in neurobiology and immunology, influencing the synthesis of several bioactive compounds, including neurotransmitters and neuroprotective agents. Dysregulation of HAAO has been linked to various neurological disorders, including schizophrenia and mood disorders, making it a potential therapeutic target. The study of HAAO is further heightened by the increasing recognition of its role in modulating neuronal health and inflammation. Recent advancements in recombinant protein technology have enabled the production of HAAO for detailed structural and functional analyses, facilitating a deeper understanding of its enzymatic mechanisms and interactions with other biomolecules. By exploring the biochemistry of HAAO, researchers aim to develop innovative strategies for intervention in associated diseases, paving the way for novel treatments and enhancing our knowledge of tryptophan metabolism's impact on human health. This research not only enhances our fundamental understanding of metabolic pathways but also underscores the potential of HAAO as a biomarker for psychiatric conditions, highlighting its significance in both basic and applied science.
