Analytical Data
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Gene name
HRMT1L6
- Application
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Alternative Names
ANM6_HUMAN; Chromobox protein homolog 7; FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase like 6.; HRMT1L6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96LA8
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Expression Region
1-375aa
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AA Sequence
MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC YSDVSVHEEM IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC AQAGARRVYA VEASAIWQQA REVVRFNGLE DRVHVLPGPV ETVELPEQVD AIVSEWMGYG LLHESMLSSV LHARTKWLKE GGLLLPASAE LFIAPISDQM LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG LSGEDVLARP QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP RRLRVLLRYK VGDQEEKTKD FAMED
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Molecular Weight
41.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRMT1L6, also known as Histone Methyltransferase 1 Like 6, is an enzyme belonging to the family of protein arginine methyltransferases. It plays a crucial role in the post-translational modification of histones, which is essential for regulating gene expression and maintaining chromatin structure. The research surrounding HRMT1L6 has gained momentum due to its involvement in various biological processes, including cellular differentiation and development. Studies have shown that abnormal regulation of HRMT1L6 and its associated pathways can contribute to several diseases, including cancers, neurodegenerative disorders, and metabolic syndromes. Recent advances in molecular biology techniques have enabled scientists to investigate the precise mechanisms by which HRMT1L6 influences transcriptional regulation and its interactions with other epigenetic modifiers. Furthermore, understanding the functional roles of HRMT1L6 in different tissues and developmental stages could provide new insights into targeted therapies. The recombinant expression of HRMT1L6 protein is critical for characterizing its enzymatic activity and potential as a therapeutic target. This has opened new avenues for drug discovery and development aimed at modulating HRMT1L6's activity to restore normal epigenetic functions disrupted in various pathological conditions. Overall, the study of HRMT1L6 not only enhances our understanding of epigenetic regulation but also holds promise for innovative approaches in treating diseases linked to dysregulated histone methylation patterns.
