Analytical Data
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基因名
HRMT1L3
- Application
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别名
2010005E20Rik; 2410018A17Rik; AL033309; ANM3_HUMAN; Heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 3; Heterogeneous nuclear ribonucleoprotein methyltransferase like 3; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 3; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3; HMT1 hnRNP methyltransferase like 3; HMT1 hnRNP methyltransferase like 3 S. cerevisiae; HMT1-like 3; hnRNP methyltransferase like 3; HRMT1L3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60678
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表达区间
2-531aa
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氨基酸序列
CSLASGATG GRGAVENEED LPELSDSGDE AAWEDEDDAD LPHGKQQTPC LFCNRLFTSA EETFSHCKSE HQFNIDSMVH KHGLEFYGYI KLINFIRLKN PTVEYMNSIY NPVPWEKEEY LKPVLEDDLL LQFDVEDLYE PVSVPFSYPN GLSENTSVVE KLKHMEARAL SAEAALARAR EDLQKMKQFA QDFVMHTDVR TCSSSTSVIA DLQEDEDGVY FSSYGHYGIH EEMLKDKIRT ESYRDFIYQN PHIFKDKVVL DVGCGTGILS MFAAKAGAKK VLGVDQSEIL YQAMDIIRLN KLEDTITLIK GKIEEVHLPV EKVDVIISEW MGYFLLFESM LDSVLYAKNK YLAKGGSVYP DICTISLVAV SDVNKHADRI AFWDDVYGFK MSCMKKAVIP EAVVEVLDPK TLISEPCGIK HIDCHTTSIS DLEFSSDFTL KITRTSMCTA IAGYFDIYFE KNCHNRVVFS TGPQSTKTHW KQTVFLLEKP FSVKAGEALK GKVTVHKSKK DPRSLTVTLT LNNSTQTYGL Q
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分子量
59.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HRMT1L3, a member of the lysine methyltransferase family, is primarily implicated in the methylation of histone proteins, a crucial process in the regulation of gene expression and chromatin structure. The enzyme is known for its role in epigenetic modifications, which influence various biological processes, including cellular differentiation, proliferation, and response to environmental stimuli. Dysregulation of HRMT1L3 has been linked to various diseases, including cancers, where altered methylation patterns can lead to abnormal gene expression. Given its significance in epigenetics and potential as a therapeutic target, the study of HRMT1L3 recombinant protein is essential for understanding its functional mechanisms and interactions within the cell. Research into the structure and activity of HRMT1L3 not only sheds light on the molecular basis of its enzymatic function but also paves the way for the development of novel inhibitors that could modulate its activity. As such, the recombinant production of HRMT1L3 allows for detailed biochemical studies and the exploration of its role in chromatin dynamics and gene regulation, offering insights that could contribute to targeted cancer therapies and advancements in epigenetic research.
