Analytical Data
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基因名
GZMH
- Application
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别名
GZMH;CGL2;CTSGL2;Granzyme H
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20718
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表达区间
21-246aa
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氨基酸序列
IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL TAAHCQGSSI NVTLGAHNIK EQERTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKW TTAVRPLRLP SSKAQVKPGQ LCSVAGWGYV SMSTLATTLQ EVLLTVQKDC QCERLFHGNY SRATEICVGD PKKTQTGFKG DSGGPLVCKD VAQGILSYGN KKGTPPGVYI KVSHFLPWIK RTMKRL
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分子量
28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GZMH, or Granzyme H, is a serine protease belonging to the granzyme family, which plays a crucial role in the immune response, particularly in the activity of cytotoxic T lymphocytes and natural killer cells. These enzymes are released by immune cells to induce apoptosis in target cells, such as virus-infected cells or tumor cells. The study of GZMH has gained significance as researchers seek to understand its structure, function, and potential therapeutic applications, particularly in cancer immunotherapy. Understanding the mechanisms through which GZMH induces cell death could lead to novel strategies for enhancing anti-tumor immunity and designing targeted therapies. The recombinant production of GZMH offers the opportunity to study its biochemical properties and functional activities in detail, facilitating insights into its role in immune regulation and identifying potential inhibitors or activators that could modulate its action. Previous studies have indicated that granzyme H may also have implications in autoimmune diseases and inflammatory conditions, thus broadening its relevance beyond cancer research. As the field of immunology evolves, GZMH represents a promising target for therapeutic interventions aimed at harnessing the immune system for disease management.
