Analytical Data
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Gene name
CD42d
- Application
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Alternative Names
CD42d；Platelet glycoProtein V
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40197
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Expression Region
1-560aa
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AA Sequence
MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPPPRPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVIIVFAMIKIGQLFRKLIRERALG
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Molecular Weight
60.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD42d, also known as P-selectin glycoprotein ligand-1 (PSGL-1), is a key receptor involved in the adhesion of leukocytes to endothelial cells during inflammatory responses. Research on CD42d recombinant protein has garnered significant attention due to its critical role in mediating cell interactions within the vascular system, particularly in the context of immune responses, thrombosis, and cancer metastasis. The ability of CD42d to bind to selectins on the surface of activated platelets and endothelial cells underscores its importance in facilitating leukocyte rolling and transmigration to sites of inflammation. Scientists have been exploring the therapeutic potential of CD42d-based interventions to modulate excessive inflammation and improve outcomes in conditions such as atherosclerosis, acute coronary syndromes, and tumor progression. Additionally, the generation of CD42d recombinant proteins enables the study of its structural and functional properties, providing insights into its interaction mechanisms and offering potential avenues for the development of novel therapeutics aimed at interfering with leukocyte adhesion processes. Overall, the investigation of CD42d recombinant proteins not only enhances our understanding of the basic immunological mechanisms but also opens up new possibilities for clinical applications in managing inflammatory diseases and improving immune responses.
