Analytical Data
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基因名
INGAP
- Application
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别名
INGAP；Pancreatic beta cell growth factor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q06141
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表达区间
27-175aa
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氨基酸序列
EEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD
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分子量
43.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INGAP (Insulinoma-Associated Protein) is a crucial peptide that has emerged as a significant subject of research in the context of diabetes and pancreatic function. It was originally identified in insulinoma cells, where it plays a role in the regulation of insulin secretion and cellular proliferation. The interest in INGAP has intensified due to its potential therapeutic implications in regenerative medicine, particularly in the regeneration of pancreatic β-cells, which are critical in maintaining glucose homeostasis. Studies have shown that INGAP can promote the differentiation and survival of these insulin-producing cells, making it a promising candidate for treating type 1 and type 2 diabetes. Moreover, exploring the molecular mechanisms underlying INGAP’s effects can reveal new insights into cellular signaling pathways and regenerative processes. As researchers delve deeper into the structure and function of INGAP, recombinant protein technologies have enabled the production of INGAP for further functional studies, paving the way for potential clinical applications. The ongoing investigation into INGAP’s role in pancreatic health and its regenerative capabilities highlights not only its biological significance but also its potential impact on future diabetes therapies.
