Analytical Data
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Gene name
GTSF1
- Application
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Alternative Names
GTSF1;FAM112B;Gametocyte-specific factor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WW33
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Expression Region
1-167aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEETYTD SLDPEKLLQC PYDKNHQIRA CRFPYHLIKC RKNHPDVASK LATCPFNARH QVPRAEISHH ISSCDDRSCI EQDVVNQTRS LRQETLAEST WQCPPCDEDW DKDLWEQTST PFVWGTTHYS DNNSPASNIV TEHKNNLASG MRVPKSLPYV LPWKNNGNAQ
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Molecular Weight
22 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GTSF1 (Germ Cell Tumor Susceptibility Factor 1) is a protein initially linked to germ cell development and testicular germ cell tumors. Its role in cancer biology has garnered significant interest, particularly in understanding its involvement in the regulation of germ cell fate and tumorigenesis. The research surrounding GTSF1 focuses on its structural characteristics, expression patterns, and functional mechanisms, which may help elucidate its contributions to oncogenesis. Studies indicate that GTSF1 interacts with various cellular pathways, including those involved in cell proliferation and apoptosis, suggesting its potential as a regulatory factor in both normal germ cell differentiation and tumor development. Moreover, the protein has been implicated in modulating the response to environmental stressors and may play a role in epigenetic regulation. This has led researchers to explore its potential as a biomarker for testicular cancer and other germ cell-related malignancies. The ongoing investigation into GTSF1's functions and interactions continues to provide insights into germ cell biology and may reveal novel therapeutic targets for germ cell tumors. Understanding GTSF1 could pave the way for advancements in cancer diagnosis and treatment, highlighting the importance of this protein in the field of oncology and reproductive health. As research progresses, a comprehensive understanding of GTSF1's role could contribute to deeper insights into tumorigenesis and enhance our capabilities in developing targeted therapies for germ cell tumors.
