Analytical Data
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基因名
HOXD13
- Application
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别名
HOXD13; HOX4I; Homeobox protein Hox-D13; Homeobox protein Hox-4I
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35453
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表达区间
1-343aa
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氨基酸序列
MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPPSAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS
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分子量
64.68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXD13 is a member of the homeobox gene family, which plays a crucial role in the regulation of embryonic development, particularly in limb formation and morphogenesis. Mutations or dysregulation of HOXD13 are associated with several congenital malformations, including synpolydactyly and other limb patterning disorders. Given its significance in developmental biology, recombinant HOXD13 protein has garnered attention as a valuable tool for understanding the molecular mechanisms underlying limb development and associated pathologies. The ability to produce HOXD13 in a recombinant form allows researchers to investigate its functional properties, protein interactions, and downstream signaling pathways in a controlled environment. By analyzing the recombinant protein, scientists can explore how specific mutations affect its activity and elucidate the gene's role in transcriptional regulation during development. Furthermore, this research has potential implications for therapeutic strategies aimed at correcting developmental anomalies caused by HOXD13-related disorders. By deepening our understanding of HOXD13 through recombinant protein studies, we can contribute to the broader field of developmental biology and regenerative medicine.
