Analytical Data
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Gene name
HOXD11
- Application
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Alternative Names
Homeo box 4F; Homeo box D11; Homeobox D11; Homeobox protein Hox-4F; Homeobox protein Hox-D11; Hox-4F; HOX4; HOX4F; HOXD11; HXD11_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31277
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Expression Region
1-338aa
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AA Sequence
MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGGYAPYYAAAAAAAAAAAAAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEGSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTGNPLF
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Molecular Weight
37.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXD11 is a member of the homeobox gene family, which plays a crucial role in the regulation of limb and axial skeletal development during embryogenesis. The proper expression and function of HOXD11 are essential for normal bone formation and growth. Studies have shown that mutations or dysregulation of HOXD11 can lead to developmental disorders such as syndactyly and polydactyly, highlighting its importance in morphogenetic processes. Given its significant role in shaping vertebrate anatomy, researchers have focused on the recombinant expression of HOXD11 to better understand its functional mechanisms at the molecular level. The production of HOXD11 recombinant proteins allows for detailed analysis of its interactions with other proteins and its involvement in cellular pathways that govern skeletal development. Additionally, investigating HOXD11 through recombinant methodologies can aid in the identification of potential therapeutic targets for congenital limb deformities and other related conditions. As research progresses, understanding the biochemical properties and biological functions of HOXD11 will contribute to the broader field of developmental biology and genetics, paving the way for innovative approaches in regenerative medicine and developmental therapeutics.
