Analytical Data
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Gene name
TXNIP
- Application
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Alternative Names
TXNIP；VDUP1；Thioredoxin-interacting Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H3M7
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Expression Region
1-391aa
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AA Sequence
MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC VDYWVKAFLD RPSQPTQETK KNFEVVDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV SARIDRKGFC EGDEISIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDVIPE DHRLESPTTP LLDDMDGSQD SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q
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Molecular Weight
58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXNIP (thioredoxin-interacting protein) is a crucial signaling molecule that has garnered significant attention in the fields of diabetes and cardiovascular research due to its role in cellular redox regulation and glucose metabolism. Initially characterized as a modulator of the thioredoxin system, TXNIP is known to interact with thioredoxin, thereby inhibiting its antioxidant functions. Elevated levels of TXNIP have been associated with oxidative stress, inflammation, and apoptosis, particularly in diabetic conditions. Recent studies have highlighted its involvement in regulating insulin signaling and glucose homeostasis, suggesting that TXNIP may serve as a critical link between oxidative stress and metabolic disorders. Research has focused on the development of recombinant TXNIP proteins to elucidate its functional mechanisms and potential therapeutic applications. By producing and studying these recombinant proteins, researchers aim to dissect the molecular pathways mediated by TXNIP, investigate its role in the progression of insulin resistance, and explore novel intervention strategies to mitigate its adverse effects. This area of study not only enhances our understanding of TXNIP’s biological functions but also opens new avenues for targeting TXNIP-related pathways in treating metabolic diseases, thereby contributing to the development of innovative therapies for conditions such as type 2 diabetes and cardiovascular diseases.
