Analytical Data
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Gene name
HOXB3
- Application
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Alternative Names
Homeo box 2G ; Homeo box B3; Homeobox B3; Homeobox protein Hox-2.7; Homeobox protein Hox-2G; Homeobox protein Hox-B3; Homeobox protein HoxB3; Hox 2.7; HOX 2G; HOX2; Hox2.7; HOX2G; HOXB3; HXB3_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14651
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Expression Region
1-431aa
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AA Sequence
MQKATYYDNAAAALFGGYSSYPGSNGFGFDVPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPGTNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHHGPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL
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Molecular Weight
73.81 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Homeobox gene family members, particularly HOXB3, play a crucial role in developmental processes and cellular differentiation. HOXB3 is part of the HOX gene cluster, which is known to regulate gene expression during embryogenesis and is essential for the proper formation of various tissues and organs. The implications of HOXB3 in cancer and various genetic disorders have garnered significant research interest, as alterations in HOX gene expression can lead to abnormal cell proliferation and tumorigenesis. Previous studies have shown that HOXB3 is involved in pathways influencing neuronal development and may also participate in inflammatory responses. The recombinant protein of HOXB3 is being studied not only to further understand its biological functions but also to explore its potential applications in therapeutic strategies. By harnessing recombinant DNA technology, researchers can produce HOXB3 in the laboratory, allowing for in-depth analysis of its structural and functional properties. This ongoing research aids in elucidating the mechanisms through which HOXB3 exerts its effects in normal physiology and disease states, paving the way for potential interventions in conditions where HOXB3 plays a pivotal role. Overall, studying HOXB3 recombinant protein offers valuable insights into its biological significance and potential therapeutic applications in oncology and regenerative medicine.
