Analytical Data
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Gene name
GNGT1
- Application
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Alternative Names
GNGT1;Guanine nucleotide-binding Protein G(T) subunit gamma-T1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63211
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Expression Region
1-71aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPVINIE DLTEKDKLKM EVDQLKKEVT LERMLVSKCC EEVRDYVEER SGEDPLVKGI PEDKNPFKEL KGGC
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Molecular Weight
11 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNGT1, a member of the G protein family, plays a crucial role in cellular signaling pathways, particularly in phototransduction in the retinal cells of vertebrates. This protein forms a heterotrimeric complex with G-alpha and G-beta/gamma subunits, playing an essential role in mediating the effects of various external stimuli on cellular responses. The study of GNGT1 as a recombinant protein has gained significant traction due to its potential implications in understanding the molecular mechanisms underlying vision and its associated disorders. Researchers are increasingly interested in characterizing this protein to explore its structural and functional properties, which can provide insights into its role in retinal health and potentially lead to therapeutic targets for retinal degenerative diseases. Recombinant GNGT1 can be produced in various expression systems, allowing for detailed biochemical and biophysical analysis. This research aims to elucidate the signaling pathways mediated by GNGT1, paving the way for innovative strategies in treating vision disorders linked to G protein-coupled signaling dysregulation. The ongoing investigations into the functional dynamics of GNGT1 may not only enhance our understanding of vision biology but could also contribute to developing new interventions for various related diseases, highlighting the importance of recombinantly expressed GNGT1 in biomedical research.
