Analytical Data
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Gene name
DNAJA1
- Application
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Alternative Names
DNAJA1；DNAJ2；HDJ2；HSJ2；DnaJ homolog subfamily A member 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31689
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Expression Region
1-394aa
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AA Sequence
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC
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Molecular Weight
52.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJA1, a member of the DnaJ/Hsp40 family of heat shock proteins, plays a crucial role in cellular protein folding and stress response. It functions as a co-chaperone, assisting in the proper folding of proteins and preventing the aggregation of misfolded proteins, which can lead to cellular dysfunction and contribute to various diseases, including neurodegenerative disorders. Due to its essential role in maintaining proteostasis, DNAJA1 has garnered significant attention in the fields of molecular biology and biochemistry. Research has shown that its expression can be upregulated under stress conditions, highlighting its potential as a therapeutic target or biomarker for diseases related to protein misfolding. Furthermore, studies have revealed that DNAJA1 interacts with numerous client proteins, influencing their stability and functionality. This has led to increased interest in the development of DNAJA1 recombinant proteins for functional assays, structural studies, and potential therapeutic applications. Understanding the intricate mechanisms of DNAJA1 and its interactions could provide insights into the molecular basis of various pathologies and pave the way for novel interventions in related diseases. Thus, the investigation of DNAJA1 recombinant proteins is a promising area of research with implications for improving our understanding of cellular stress responses and the development of strategies to combat diseases associated with protein misfolding.
