Analytical Data
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基因名
HIST1H4H
- Application
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别名
dJ160A22.1; dJ160A22.2; dJ221C16.1; dJ221C16.9; FO108; H4; H4.k; H4/a; H4/b; H4/c; H4/d; H4/e; H4/g; H4/h; H4/I; H4/j; H4/k; H4/m; H4/n; H4/p; H4_HUMAN; H4F2; H4F2iii; H4F2iv; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4M; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P62805
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表达区间
31-103aa
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氨基酸序列
TKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
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分子量
33.77 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H4H is a gene that encodes a histone protein, specifically a member of the histone H4 family, which plays a critical role in the compaction and regulation of DNA within the nucleus of eukaryotic cells. Histones serve as fundamental components of chromatin, allowing for the organization of genomic DNA into a compact structure, thereby influencing gene expression, DNA replication, and repair processes. Research on HIST1H4H and its recombinant protein has gained significant attention due to its implications in various biological and pathological processes, including cellular differentiation, development, and cancer. Understanding the structure and function of the HIST1H4H-derived proteins can provide insights into epigenetic modifications and the mechanisms underlying chromatin dynamics. Advances in molecular biology techniques, such as recombinant DNA technology, have facilitated the production of this histone in vitro, allowing researchers to explore its biophysical properties, interactions with other chromatin components, and the potential impact on gene regulation. Additionally, abnormalities in histone modifications have been associated with various diseases, particularly cancer, highlighting the importance of elucidating the role of HIST1H4H in epigenetic regulation and its potential as a therapeutic target. Thus, the study of HIST1H4H recombinant protein not only enhances our understanding of histone biology but also contributes to the broader field of epigenetics and its relevance to health and disease.
