Analytical Data
-
Gene name
HHATL
- Application
-
Alternative Names
HHATL; C3orf3; GUP1; KIAA1173Protein-cysteine N-palmitoyltransferase HHAT-like protein; Glycerol uptake/transporter homolog; Hedgehog acyltransferase-like protein
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9HCP6
-
Expression Region
1-504aa
-
AA Sequence
MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFRESVRPGWEYIGRKMDVADFEWVMWFTSFRNVIIFALSGHVLFAKLCTMVAPKLRSWMYAVYGALAVMGTMGPWYLLLLLGHCVGLYVASLLGQPWLCLGLGLASLASFKMDPLISWQSGFVTGTFDLQEVLFHGGSSFTVLRCASFALESCAHPDRHYSLADLLKYNFYLPFFFFGPIMTFDRFHAQVSQVEPVRREGELWHIRAQAGLSVVAIMAVDIFFHFFYILTIPSDLKFANRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVACLDHLDPPQPPKCITALYVFTETHFDRGINDWLCKYVYNHIGGEHSAVIPELAATVATFAITTLWLGPCDIVYLWSFLNCFGLNFELWMQKLAEWGPLARIEASLSVQMSRRVRALFGAMNFWAIIMYNLVSLNSLKFTELVARRLLLTGFPQTTLSILFVTYCGVQLVKERERTLALEEEQKQDKEKPE
-
Molecular Weight
83.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HHATL (Hedgehog-Associated Protein with Two Transmembrane Domains) is a critical player in the Hedgehog signaling pathway, which is essential for various developmental processes in animals. Abnormalities in Hedgehog signaling are implicated in several cancers and developmental disorders, making HHATL a potential target for therapeutic interventions. The protein was first identified due to its association with Hedgehog proteins, which are secreted ligands that regulate cell growth and differentiation. Research into the structure and function of HHATL has revealed its role as a regulatory molecule, influencing the activity and stability of Hedgehog proteins. Understanding the mechanisms by which HHATL modulates Hedgehog signaling is vital for elucidating its impact on tumorigenesis and tissue development. Recent studies have focused on characterizing the structural features of HHATL, particularly its transmembrane domains and interactions with other signaling components. This research is crucial for exploring how targeting HHATL or its interactions could lead to novel cancer therapies and enhance our understanding of Hedgehog-related developmental processes. As the field progresses, detailed investigations into the molecular dynamics of HHATL may unveil new insights into its roles in health and disease, thereby offering potential avenues for innovative treatments.
