Analytical Data
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基因名
HHATL
- Application
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别名
HHATL; C3orf3; GUP1; KIAA1173Protein-cysteine N-palmitoyltransferase HHAT-like protein; Glycerol uptake/transporter homolog; Hedgehog acyltransferase-like protein
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HCP6
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表达区间
1-504aa
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氨基酸序列
MGIKTALPAAELGLYSLVLSGALAYAGRGLLEASQDGAHRKAFRESVRPGWEYIGRKMDVADFEWVMWFTSFRNVIIFALSGHVLFAKLCTMVAPKLRSWMYAVYGALAVMGTMGPWYLLLLLGHCVGLYVASLLGQPWLCLGLGLASLASFKMDPLISWQSGFVTGTFDLQEVLFHGGSSFTVLRCASFALESCAHPDRHYSLADLLKYNFYLPFFFFGPIMTFDRFHAQVSQVEPVRREGELWHIRAQAGLSVVAIMAVDIFFHFFYILTIPSDLKFANRLPDSALAGLAYSNLVYDWVKAAVLFGVVNTVACLDHLDPPQPPKCITALYVFTETHFDRGINDWLCKYVYNHIGGEHSAVIPELAATVATFAITTLWLGPCDIVYLWSFLNCFGLNFELWMQKLAEWGPLARIEASLSVQMSRRVRALFGAMNFWAIIMYNLVSLNSLKFTELVARRLLLTGFPQTTLSILFVTYCGVQLVKERERTLALEEEQKQDKEKPE
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分子量
83.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HHATL (Hedgehog-Associated Protein with Two Transmembrane Domains) is a critical player in the Hedgehog signaling pathway, which is essential for various developmental processes in animals. Abnormalities in Hedgehog signaling are implicated in several cancers and developmental disorders, making HHATL a potential target for therapeutic interventions. The protein was first identified due to its association with Hedgehog proteins, which are secreted ligands that regulate cell growth and differentiation. Research into the structure and function of HHATL has revealed its role as a regulatory molecule, influencing the activity and stability of Hedgehog proteins. Understanding the mechanisms by which HHATL modulates Hedgehog signaling is vital for elucidating its impact on tumorigenesis and tissue development. Recent studies have focused on characterizing the structural features of HHATL, particularly its transmembrane domains and interactions with other signaling components. This research is crucial for exploring how targeting HHATL or its interactions could lead to novel cancer therapies and enhance our understanding of Hedgehog-related developmental processes. As the field progresses, detailed investigations into the molecular dynamics of HHATL may unveil new insights into its roles in health and disease, thereby offering potential avenues for innovative treatments.
