Analytical Data
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基因名
uPA
- Application
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别名
uPA；UPA；Proline-rich acidic Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P00749
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表达区间
21-431aa
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氨基酸序列
SNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTC YEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQ KTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVI SATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTL AHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGK ENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTD SCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR SHTKEENGLAL
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of urokinase-type plasminogen activator (uPA) recombinant proteins has gained significant attention in the fields of cancer research, thrombosis, and tissue remodeling due to the pivotal role that uPA plays in physiological and pathological processes. uPA is a serine protease that converts plasminogen to plasmin, facilitating extracellular matrix degradation and cellular invasion, which are essential mechanisms in tumor metastasis and angiogenesis. Dysregulation of uPA activity is implicated in various malignancies, making it a potential biomarker for cancer progression and a target for therapeutic intervention. The advent of recombinant DNA technology has enabled the production of uPA in heterologous systems, allowing for the generation of high-purity recombinant proteins that can be used for functional studies, drug development, and potential therapeutic applications. Research focusing on the structural and functional characterization of uPA, as well as its interactions with specific inhibitors and receptors, has provided insights into its enzymatic mechanism and regulatory pathways. Furthermore, recombinant uPA has been explored as a tool in drug delivery systems and as a component of biosensors, highlighting its versatility beyond conventional therapeutic applications. As the understanding of uPA's roles continues to evolve, the development of recombinant uPA proteins promises to enhance diagnostic and therapeutic strategies, providing a foundational aspect of translational research in oncology and related fields.
