Analytical Data
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基因名
HES4
- Application
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别名
HES4; BHLHB42; Transcription factor HES-4; hHES4; Class B basic helix-loop-helix protein 42; bHLHb42; Hairy and enhancer of split 4; bHLH factor Hes4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HCC6
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表达区间
1-221aa
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氨基酸序列
MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPWLR
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分子量
49.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HES4, or Hairy and Enhancer of Split 4, is a member of the basic helix-loop-helix (bHLH) transcription factor family, which plays a crucial role in the regulation of developmental processes and cell fate determination. It is known to be involved in the Notch signaling pathway, a fundamental mechanism that influences cell differentiation, proliferation, and apoptosis. Research has shown that HES4 is particularly significant in the development of the central nervous system and in the maintenance of neural stem cells. Aberrations in HES4 expression have been linked to various neurodevelopmental disorders and cancers, highlighting its potential as a therapeutic target. The study of HES4 recombinant protein is essential for understanding its functional mechanisms, including how it interacts with other proteins and transcription factors in the nucleus. By utilizing recombinant DNA technology to produce HES4 protein, researchers can analyze its structural properties, binding affinities, and regulatory effects on target genes. This research not only enhances our understanding of HES4's role in normal physiological conditions but also provides insights into its involvement in pathological states. Overall, the investigation of HES4 recombinant protein offers a promising avenue for advancing knowledge in developmental biology, neurobiology, and potential therapeutic interventions.
