Analytical Data
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基因名
GMNN
- Application
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别名
GMNN;Geminin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75496
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表达区间
1-209aa
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氨基酸序列
MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS SSTDAKPCI
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GMNN (Geminin) is a crucial regulatory protein involved in cell cycle control, particularly in the coordination of DNA replication and mitosis. Its primary function is to prevent re-replication of DNA by inhibiting the loading of DNA polymerase onto replication origins during the S phase of the cell cycle. Dysregulation of GMNN has been implicated in various cancers, making it a significant focus of research in tumor biology. Studies have shown that aberrant expression of GMNN can contribute to genomic instability and uncontrolled cell proliferation. Therefore, understanding the structure and function of GMNN, particularly through the study of its recombinant proteins, is essential for elucidating its role in cell cycle regulation and cancer progression. Researchers are employing various recombinant DNA technology techniques to produce GMNN in vitro, allowing for detailed biochemical analyses and functional assays. This work aims to provide insights into the molecular mechanisms by which GMNN operates, its interactions with other cell cycle regulators, and its potential as a therapeutic target in cancer treatment. Overall, the study of GMNN recombinant proteins is positioned at the intersection of cell biology and cancer research, with the potential to uncover novel avenues for therapeutic intervention.
