Analytical Data
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Gene name
GDI1
- Application
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Alternative Names
GDI1；RAB5PLAB;Ras-related Protein Rab-5A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31150
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Expression Region
1-447aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGS MDEEYDV IVLGTGLTEC ILSGIMSVNG KKVLH MDRNP YYGGESSSIT PLEELYKRFQ LLEGPPESMG RGRDWNVDLI PKFLMANGQL VKMLLYTEVT RYLDFKVVEG SFVYKGGKIY KVPSTETEAL ASNLMGMFEK RRFRKFLVFV ANFDENDPKT FEGVDPQTTS MRDVYRKFDL GQDVIDFTGH ALALYRTDDY LDQPCLETVN RIKLYSESLA RYGKSPYLYP LYGLGELPQG FARLSAIYGG TYMLNKPVDD IIMENGK VVG VKSEGEVARC KQLICDPSYI PDRVRKAGQV IRIICILSHP IKNTNDANSC QIIIPQNQVN RKSDIYVCMI SYAHNVAAQG KYIAIASTTV ETTDPEKEVE PALELLEPID QKFVAISDLY EPIDDGCESQ VFCSCSYDAT THFETTCNDI KDIYKRMAGT AFDFENMKRK QNDVFGEAEQ
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Molecular Weight
51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDI1 (GDP-dissociation inhibitor 1) is a pivotal regulatory protein that plays a critical role in the intracellular signaling pathways involving small GTPases, such as Rab proteins. These proteins are essential for various cellular processes, including vesicle trafficking, cellular growth, and differentiation. Mutations or dysregulation of GDI1 have been linked to several neurological disorders and cancers, highlighting its significance in maintaining cellular homeostasis. Research on recombinant GDI1 has gained momentum as scientists strive to understand its functional mechanisms and interactions with GTPases. The ability to produce GDI1 in recombinant forms allows for detailed structural and biochemical studies, facilitating the elucidation of its role in the modulation of GTPase activities. Investigating GDI1's structure-function relationship can provide insights into its regulatory mechanisms and potential as a therapeutic target. Furthermore, recombinant GDI1 can be utilized in drug screening assays to identify compounds that modulate its activity, representing a promising avenue for the development of novel treatments for diseases linked to GDI1 dysfunction. Overall, the study of recombinant GDI1 is crucial for advancing our understanding of intracellular signaling and developing potential interventions for related disorders.
