Analytical Data
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基因名
CYP19A1
- Application
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别名
CYP19A1；ARO1；CYAR；CYP19；Aromatase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11511
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表达区间
1-503aa
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氨基酸序列
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
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分子量
62.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CYP19A1, also known as aromatase, is an essential enzyme in steroidogenesis responsible for the conversion of androgens to estrogens, making it a key player in various physiological and pathological processes, including sexual development, reproductive function, and certain hormone-dependent cancers. Dysregulation of CYP19A1 expression and activity has been implicated in estrogen-related disorders, prompting extensive research into its structure, function, and regulation. The study of CYP19A1 recombinant proteins has gained significant attention, particularly in the field of biochemistry and pharmacology, as these proteins provide a valuable tool for understanding the enzyme's kinetic properties, substrate specificity, and interaction with inhibitors. This research has implications for developing targeted therapies for conditions such as breast cancer and endometriosis, where modulation of estrogen levels is critical. Furthermore, recombinant CYP19A1 can be utilized in drug screening assays and the exploration of endocrine disruptors, contributing to a broader understanding of hormonal regulation in health and disease. Overall, investigations into CYP19A1 recombinant proteins are pivotal for advancing therapeutic strategies and enhancing our comprehension of the intricate hormonal interplay within the human body.
