Analytical Data
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Gene name
M747K
- Application
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Alternative Names
M747K；
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Species
Thermus aquaticus
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P19821
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Expression Region
293-832aa
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AA Sequence
ALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERKAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
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Molecular Weight
61.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The M747K recombinant protein has garnered significant attention in the field of biomedical research due to its potential implications for understanding viral pathogenesis and developing therapeutic strategies. This protein is derived from a variant of the viral genome that exhibits mutations associated with increased virulence and adaptation to host environments. Researchers are particularly interested in the M747K variant because it provides insights into how changes in protein structure can influence viral replication, evasion of host immune responses, and overall pathogenicity. Studies have shown that the M747K mutation affects the protein's interaction with host cell receptors, potentially altering the virus's infectivity and its ability to trigger immune responses. As a result, investigations into the M747K recombinant protein aim to elucidate the molecular mechanisms underlying these changes, which could lead to the identification of novel therapeutic targets. Furthermore, the M747K variant has implications for vaccine development, as understanding its structure and function may inform the design of more effective vaccines that can elicit robust immune responses against circulating viral strains. Overall, the study of the M747K recombinant protein is crucial for advancing our knowledge of viral evolution, improving disease prevention strategies, and addressing challenges posed by emerging infectious diseases.
