Analytical Data
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Gene name
TCIRG1
- Application
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Alternative Names
TCIRG1；ATP6N1C；ATP6V0A3；V-type proton ATPase 116 kDa subunit a 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13488
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Expression Region
1-614aa
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AA Sequence
MTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQE LQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHK CLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPTLIRTNR FTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLF ALAMVLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFS RATSIFPSGWSVAAMANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPFGI DPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRL LLETLPELTFLLGLFGYLVFLVIYKWLCVWAARAASAPSILIHFINMFLF SHSPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRR PADRQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQ AIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREV GVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGT GYKLSPFTFAATDD
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TCIRG1 (T-cell immune regulator 1) is a gene that encodes a subunit of the V-ATPase, an essential protein complex involved in proton transport and cellular pH regulation. This proton pump plays a critical role in various physiological processes, including bone resorption, immune response, and endosomal/lysosomal acidification. Mutations in TCIRG1 have been associated with osteopetrosis, a genetic disorder characterized by excessive bone density due to impaired osteoclast function. As a result, studying TCIRG1 and its recombinant protein can provide significant insights into the molecular mechanisms underlying bone metabolism and immune regulation. The development of recombinant TCIRG1 proteins offers opportunities for therapeutic intervention and potential disease modeling. By gaining a deeper understanding of its structure and function, researchers aim to elucidate its role in pathology and explore novel avenues for treatment, particularly in bone metabolic disorders. Thus, TCIRG1 serves as a crucial target within biomedical research, with implications for both basic science and clinical application.
