Analytical Data
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基因名
TCIRG1
- Application
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别名
TCIRG1；ATP6N1C；ATP6V0A3；V-type proton ATPase 116 kDa subunit a 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13488
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表达区间
1-614aa
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氨基酸序列
MTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQE LQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHK CLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPTLIRTNR FTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLF ALAMVLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFS RATSIFPSGWSVAAMANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPFGI DPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRL LLETLPELTFLLGLFGYLVFLVIYKWLCVWAARAASAPSILIHFINMFLF SHSPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRR PADRQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQ AIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREV GVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGT GYKLSPFTFAATDD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCIRG1 (T-cell immune regulator 1) is a gene that encodes a subunit of the V-ATPase, an essential protein complex involved in proton transport and cellular pH regulation. This proton pump plays a critical role in various physiological processes, including bone resorption, immune response, and endosomal/lysosomal acidification. Mutations in TCIRG1 have been associated with osteopetrosis, a genetic disorder characterized by excessive bone density due to impaired osteoclast function. As a result, studying TCIRG1 and its recombinant protein can provide significant insights into the molecular mechanisms underlying bone metabolism and immune regulation. The development of recombinant TCIRG1 proteins offers opportunities for therapeutic intervention and potential disease modeling. By gaining a deeper understanding of its structure and function, researchers aim to elucidate its role in pathology and explore novel avenues for treatment, particularly in bone metabolic disorders. Thus, TCIRG1 serves as a crucial target within biomedical research, with implications for both basic science and clinical application.
