Analytical Data
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基因名
MYH11
- Application
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别名
MYH11；KIAA0866；Myosin-11
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35749
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MYH11, a gene encoding the smooth muscle myosin heavy chain, plays a crucial role in the regulation of smooth muscle contraction and vascular function. Its involvement in various cardiovascular diseases, particularly those associated with vascular remodeling and hypertension, has made it a significant focus of research. Studies have shown that mutations and abnormalities in MYH11 can lead to conditions such as familial thoracic aortic aneurysms and dissections, indicating its importance in maintaining vascular integrity. The production of recombinant MYH11 protein offers a valuable tool for investigating the molecular mechanisms underlying smooth muscle pathology and the functional consequences of genetic variations. By studying this protein, researchers aim to elucidate its role in smooth muscle contraction dynamics, protein interactions, and implications in disease processes. Furthermore, recombinant MYH11 can be used in high-throughput screening for potential therapeutic agents that target cardiovascular diseases. Therefore, understanding the structure and function of MYH11 at a molecular level is essential for developing targeted therapies and enhancing our knowledge of cardiovascular physiology and pathophysiology.
