Analytical Data
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Gene name
FBXO6
- Application
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Alternative Names
FBXO6；FBG2；FBS2;F-box only Protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRD1
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Expression Region
1-293aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMDAPHSK AALDSINELP ENILLELFTH VPARQLLLNC RLVCSLWRDL IDLMTLWKRK CLREGFITKD WDQPVADWKI FYFLRSLHRN LLRNPCAEED MFAWQIDFNG GDRWKVESLP GAHGTDFPDP KVKKYFVTSY EMCLKSQLVD LVAEGYWEEL LDTFRPDIVV KDWFAARADC GCTYQLKVQL ASADYFVLAS FEPPPVTIQQ WNNATWTEVS YTFSDYPRGV RYILFQHGGR DTQYWAGWYG PRVTNSSIVV SPKMTRNQAS SEAQPGQKHG QEEAAQSPYR AVVQIF
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO6 is an essential component of the F-box protein family, which primarily functions in the ubiquitin-proteasome pathway, a crucial mechanism for protein degradation and regulation in eukaryotic cells. As an F-box protein, FBXO6 interacts with substrates to tag them for degradation, predominantly recognizing misfolded or damaged proteins. This has significant implications in cellular homeostasis, signaling pathways, and responses to stress. Research on FBXO6 has garnered attention due to its potential role in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes, where dysregulation of protein degradation pathways is often observed. Moreover, FBXO6 has been implicated in the modulation of the critical tumor suppressor p53, indicating its involvement in cell cycle regulation and apoptosis. Recent studies have also highlighted the potential of FBXO6 as a therapeutic target, given its influence on cellular functions and disease progression. Understanding the structure and function of FBXO6, particularly through recombinant protein expression and characterization, can provide insights into its role in pathology and aid in the development of novel therapeutic strategies. This makes FBXO6 an attractive focus for ongoing biological and biomedical research, aiming to elucidate its precise mechanisms and potential as a target for intervention in various diseases.
