Analytical Data
-
基因名
FBXO6
- Application
-
别名
FBXO6；FBG2；FBS2;F-box only Protein 6
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9NRD1
-
表达区间
1-293aa
-
氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMDAPHSK AALDSINELP ENILLELFTH VPARQLLLNC RLVCSLWRDL IDLMTLWKRK CLREGFITKD WDQPVADWKI FYFLRSLHRN LLRNPCAEED MFAWQIDFNG GDRWKVESLP GAHGTDFPDP KVKKYFVTSY EMCLKSQLVD LVAEGYWEEL LDTFRPDIVV KDWFAARADC GCTYQLKVQL ASADYFVLAS FEPPPVTIQQ WNNATWTEVS YTFSDYPRGV RYILFQHGGR DTQYWAGWYG PRVTNSSIVV SPKMTRNQAS SEAQPGQKHG QEEAAQSPYR AVVQIF
-
分子量
36 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXO6 is an essential component of the F-box protein family, which primarily functions in the ubiquitin-proteasome pathway, a crucial mechanism for protein degradation and regulation in eukaryotic cells. As an F-box protein, FBXO6 interacts with substrates to tag them for degradation, predominantly recognizing misfolded or damaged proteins. This has significant implications in cellular homeostasis, signaling pathways, and responses to stress. Research on FBXO6 has garnered attention due to its potential role in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes, where dysregulation of protein degradation pathways is often observed. Moreover, FBXO6 has been implicated in the modulation of the critical tumor suppressor p53, indicating its involvement in cell cycle regulation and apoptosis. Recent studies have also highlighted the potential of FBXO6 as a therapeutic target, given its influence on cellular functions and disease progression. Understanding the structure and function of FBXO6, particularly through recombinant protein expression and characterization, can provide insights into its role in pathology and aid in the development of novel therapeutic strategies. This makes FBXO6 an attractive focus for ongoing biological and biomedical research, aiming to elucidate its precise mechanisms and potential as a target for intervention in various diseases.
