Analytical Data
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Gene name
GPR45
- Application
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Alternative Names
Probable G-protein coupled receptor 45. PSP24-1. PSP24-alpha
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5Y3
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Expression Region
1-372aa
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AA Sequence
MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV
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Molecular Weight
68.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR45, also known as G protein-coupled receptor 45, is a member of the G protein-coupled receptor (GPCR) family, which plays critical roles in various physiological processes, including signal transduction, immune responses, and neurological functions. Research on GPR45 has gained traction due to its potential involvement in neurodevelopmental disorders and its expression patterns in the central nervous system, particularly in regions associated with cognition and behavior. Understanding the functions of GPR45 at the molecular level can provide insights into its therapeutic potential for conditions such as schizophrenia, depression, and anxiety. The study of recombinant GPR45 proteins facilitates the examination of its structural properties, ligand-binding capabilities, and downstream signaling pathways in vitro. By utilizing recombinant techniques, researchers can produce large quantities of GPR45 for functional assays and drug discovery efforts, aiding in the identification of selective ligands that could modulate its activity. As GPCRs are critical drug targets, elucidating the biology of GPR45 can pave the way for new therapeutic strategies aimed at modulating its function, potentially leading to innovative interventions for related mental health conditions. Overall, the exploration of GPR45 and its recombinant protein is a promising avenue in neuroscience and pharmacology, with implications for understanding receptor biology and developing novel treatments.
