Analytical Data
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基因名
GPR45
- Application
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别名
Probable G-protein coupled receptor 45. PSP24-1. PSP24-alpha
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5Y3
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表达区间
1-372aa
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氨基酸序列
MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV
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分子量
68.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR45, also known as G protein-coupled receptor 45, is a member of the G protein-coupled receptor (GPCR) family, which plays critical roles in various physiological processes, including signal transduction, immune responses, and neurological functions. Research on GPR45 has gained traction due to its potential involvement in neurodevelopmental disorders and its expression patterns in the central nervous system, particularly in regions associated with cognition and behavior. Understanding the functions of GPR45 at the molecular level can provide insights into its therapeutic potential for conditions such as schizophrenia, depression, and anxiety. The study of recombinant GPR45 proteins facilitates the examination of its structural properties, ligand-binding capabilities, and downstream signaling pathways in vitro. By utilizing recombinant techniques, researchers can produce large quantities of GPR45 for functional assays and drug discovery efforts, aiding in the identification of selective ligands that could modulate its activity. As GPCRs are critical drug targets, elucidating the biology of GPR45 can pave the way for new therapeutic strategies aimed at modulating its function, potentially leading to innovative interventions for related mental health conditions. Overall, the exploration of GPR45 and its recombinant protein is a promising avenue in neuroscience and pharmacology, with implications for understanding receptor biology and developing novel treatments.
