Analytical Data
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基因名
GPR175
- Application
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别名
TPRA1; GPR175; TMEM227; PP6566; Transmembrane protein adipocyte-associated 1; Integral membrane protein GPR175; Transmembrane protein 227
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86W33
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表达区间
1-373aa
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氨基酸序列
MDTLEEVTWANGSTALPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFLIFLLWKLPSARAKIRITSSPIFITFYILVFVVALVGIARAVVSMTVSTSNAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERISLPSRRSFYVYAGILALLNLLQGLGSVLLCFDIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDETEEPDVHLPQPYAVARREGLEAAGAAGASAASYSSTQFDSAGGVAYLDDIASMPCHTGSINSTDSERWKAINA
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分子量
41.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR175, a member of the G protein-coupled receptor (GPCR) family, has garnered attention due to its potential roles in various physiological processes and disease states. Initially identified through genomic sequencing, GPR175 is expressed in several tissues, with notable levels in the brain, suggesting a role in central nervous system functions. Its ligands and specific signaling pathways remain largely undefined, which hampers a comprehensive understanding of its biological significance. Recent research has indicated that GPR175 may be involved in modulating immune responses and has implications in neurological disorders, such as depression and schizophrenia. The development of recombinant GPR175 proteins facilitates the exploration of its structure-function relationships, ligand interactions, and signaling mechanisms. By producing and characterizing the recombinant protein, researchers aim to elucidate GPR175's pharmacological profile and identify potential therapeutic targets. Additionally, understanding GPR175's role in health and disease could contribute to the development of novel drug candidates aimed at modulating GPCR activity. Overall, the study of GPR175 and its recombinant protein presents a promising avenue for advancing our knowledge of GPCR biology and its relevance in human health.
