Analytical Data
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Gene name
GPR175
- Application
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Alternative Names
TPRA1; GPR175; TMEM227; PP6566; Transmembrane protein adipocyte-associated 1; Integral membrane protein GPR175; Transmembrane protein 227
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86W33
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Expression Region
1-373aa
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AA Sequence
MDTLEEVTWANGSTALPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFLIFLLWKLPSARAKIRITSSPIFITFYILVFVVALVGIARAVVSMTVSTSNAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERISLPSRRSFYVYAGILALLNLLQGLGSVLLCFDIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDETEEPDVHLPQPYAVARREGLEAAGAAGASAASYSSTQFDSAGGVAYLDDIASMPCHTGSINSTDSERWKAINA
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Molecular Weight
41.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR175, a member of the G protein-coupled receptor (GPCR) family, has garnered attention due to its potential roles in various physiological processes and disease states. Initially identified through genomic sequencing, GPR175 is expressed in several tissues, with notable levels in the brain, suggesting a role in central nervous system functions. Its ligands and specific signaling pathways remain largely undefined, which hampers a comprehensive understanding of its biological significance. Recent research has indicated that GPR175 may be involved in modulating immune responses and has implications in neurological disorders, such as depression and schizophrenia. The development of recombinant GPR175 proteins facilitates the exploration of its structure-function relationships, ligand interactions, and signaling mechanisms. By producing and characterizing the recombinant protein, researchers aim to elucidate GPR175's pharmacological profile and identify potential therapeutic targets. Additionally, understanding GPR175's role in health and disease could contribute to the development of novel drug candidates aimed at modulating GPCR activity. Overall, the study of GPR175 and its recombinant protein presents a promising avenue for advancing our knowledge of GPCR biology and its relevance in human health.
