Analytical Data
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Gene name
AKAP11
- Application
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Alternative Names
AKAP11；AKAP220；KIAA0629；A-kinase anchor Protein 11
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UKA4
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP11 (A-Kinase Anchoring Protein 11) is a member of the AKAP family, which plays a crucial role in signaling pathways by anchoring protein kinase A (PKA) and other signaling molecules to specific subcellular locations. This spatial organization is vital for the proper functioning of various physiological processes, including cell proliferation, differentiation, and response to hormonal stimuli. Research on AKAP11 has gained momentum due to its potential implications in cardiovascular diseases, cancer, and other disorders where PKA signaling is disrupted. The ability of AKAPs to compartmentalize signaling cascades allows for fine-tuned regulatory mechanisms within cells. Because AKAP11 is expressed in multiple tissues, including the heart and brain, its functional characterization is particularly relevant for understanding disease mechanisms. Recombined AKAP11 proteins can be utilized in various experimental strategies to study their binding properties, functional roles in cellular pathways, and interactions with other proteins. These studies contribute to a larger understanding of PKA signaling dynamics and highlight potential therapeutic targets for conditions linked to aberrant protein signaling. Overall, investigating the structure and function of AKAP11 through recombinant protein techniques is a promising avenue that could lead to significant advancements in both basic and applied biomedical research.
