Analytical Data
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基因名
ACVR1C
- Application
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别名
ACVR1C；ALK7；Activin receptor type-1C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NER5
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表达区间
1-493aa
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氨基酸序列
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASV MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLP TASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPN VEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI VGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENIL GFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWE IARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQS CEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
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分子量
80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR1C, also known as Activin A receptor type 1C, is a member of the transforming growth factor-beta (TGF-β) receptor superfamily. It plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, and the regulation of inflammatory responses. The protein is known to be involved in signaling pathways that contribute to the differentiation and proliferation of cells, particularly in the context of mesodermal and ectodermal lineages. Dysregulation of ACVR1C expression or function has been implicated in several pathological conditions, including fibrotic diseases, cancer, and metabolic disorders. Research into recombinant ACVR1C protein has gained traction as scientists aim to better understand its structure, function, and potential therapeutic applications. By producing recombinant forms of ACVR1C, researchers can investigate its interactions with other signaling molecules and its role in cellular responses to stimuli. This research could pave the way for novel therapeutic strategies targeting ACVR1C-related pathways, offering new hope for the treatment of diseases characterized by aberrant TGF-β signaling. Furthermore, understanding the mechanistic details of ACVR1C function may provide insights into the development of biomolecular tools and diagnostics, potentially leading to improved patient outcomes in conditions associated with its dysregulation. As a result, studies involving the purification and characterization of recombinant ACVR1C are critical for advancing our knowledge of this important receptor and its implications in health and disease.
