Analytical Data
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Gene name
ACVR1C
- Application
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Alternative Names
ACVR1C；ALK7；Activin receptor type-1C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NER5
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Expression Region
1-493aa
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AA Sequence
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASV MLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLP TASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPN VEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI VGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENIL GFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDS ILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWE IARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQS CEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
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Molecular Weight
80 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR1C, also known as Activin A receptor type 1C, is a member of the transforming growth factor-beta (TGF-β) receptor superfamily. It plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, and the regulation of inflammatory responses. The protein is known to be involved in signaling pathways that contribute to the differentiation and proliferation of cells, particularly in the context of mesodermal and ectodermal lineages. Dysregulation of ACVR1C expression or function has been implicated in several pathological conditions, including fibrotic diseases, cancer, and metabolic disorders. Research into recombinant ACVR1C protein has gained traction as scientists aim to better understand its structure, function, and potential therapeutic applications. By producing recombinant forms of ACVR1C, researchers can investigate its interactions with other signaling molecules and its role in cellular responses to stimuli. This research could pave the way for novel therapeutic strategies targeting ACVR1C-related pathways, offering new hope for the treatment of diseases characterized by aberrant TGF-β signaling. Furthermore, understanding the mechanistic details of ACVR1C function may provide insights into the development of biomolecular tools and diagnostics, potentially leading to improved patient outcomes in conditions associated with its dysregulation. As a result, studies involving the purification and characterization of recombinant ACVR1C are critical for advancing our knowledge of this important receptor and its implications in health and disease.
