Analytical Data
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Gene name
PIEZO2
- Application
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Alternative Names
(Protein FAM38B)
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Species
Human
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H5I5
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Expression Region
2427-2661aa
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Molecular Weight
33.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PIEZO2 is a mechanically activated ion channel that plays a crucial role in various physiological processes, particularly in mechanotransduction—the conversion of mechanical stimuli into electrochemical signals. It is predominantly expressed in sensory neurons and is essential for the sensation of touch, proprioception, and pain. Mutations in the PIEZO2 gene have been linked to a range of disorders, including congenital insensitivity to pain and skeletal deformities, underscoring its significance in human health. Research into PIEZO2 recombinant proteins has gained momentum due to the need for understanding its structural and functional properties, which are pivotal for developing therapeutic strategies for PIEZO2-related conditions. Expression and purification of PIEZO2 as recombinant proteins allow researchers to investigate its biophysical characteristics and interactions at a molecular level. This foundational knowledge is critical for elucidating the precise mechanisms by which PIEZO2 responds to mechanical stimuli and coordinating cellular responses. Furthermore, defining the structure of PIEZO2 may pave the way for drug development targeting its channel activity, offering new avenues for treating disorders associated with mechanosensation. Overall, the study of PIEZO2 recombinant proteins represents a significant leap forward in neuroscience, molecular biology, and therapeutic advances, striving to bridge the gap between fundamental research and clinical applications.
