Cat: PA2000-3728

Recombinant Human KLRG2 Protein,His

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Analytical Data

  • Gene name

    KLRG2

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    KLRG2;CLEC15B;Killer cell lectin-like receptor subfamily G member 2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    A4D1S0

  • Expression Region

    1-409aa

  • AA Sequence

    MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGPESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVKLPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPAFSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHCYYFSAEAQAWEASQAFCSAYHATLPLLSHTQDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGEDNLDINCGALEEGTLVAANCSTPRPWVCAKGTQ

  • Molecular Weight

    44.9 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

KLRG2 (Killer Cell Lectin-like Receptor G2) is a type of inhibitory receptor primarily expressed on various immune cells, including natural killer (NK) cells, T cells, and memory T cell subsets. Its engagement plays a crucial role in regulating immune responses, particularly during viral infections and cancer. Research has shown that KLRG2 mediates inhibitory signals that can impact the functionality and longevity of T cells. Given its significance in immune regulation, KLRG2 has emerged as a potential target for immunotherapy. The development of recombinant KLRG2 proteins has enabled researchers to investigate its structural properties, ligand interactions, and signaling pathways in greater detail. Studying the function of KLRG2, through its recombinant forms, aids in elucidating its role in immune tolerance and potential implications in diseases such as cancer and chronic infections. Furthermore, the use of recombinant proteins facilitates the exploration of KLRG2 as a therapeutic target, offering insights into how modulation of its activity could enhance immune responses. Overall, the investigation of KLRG2 and its recombinant variants is essential for advancing our understanding of immune regulation and developing innovative strategies for cancer immunotherapy and the treatment of infectious diseases.

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