Analytical Data
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基因名
KLRG2
- Application
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别名
KLRG2；CLEC15B；Killer cell lectin-like receptor subfamily G member 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A4D1S0
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表达区间
1-409aa
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氨基酸序列
MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGPESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVKLPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPAFSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHCYYFSAEAQAWEASQAFCSAYHATLPLLSHTQDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGEDNLDINCGALEEGTLVAANCSTPRPWVCAKGTQ
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分子量
44.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLRG2 (Killer Cell Lectin-like Receptor G2) is a type of inhibitory receptor primarily expressed on various immune cells, including natural killer (NK) cells, T cells, and memory T cell subsets. Its engagement plays a crucial role in regulating immune responses, particularly during viral infections and cancer. Research has shown that KLRG2 mediates inhibitory signals that can impact the functionality and longevity of T cells. Given its significance in immune regulation, KLRG2 has emerged as a potential target for immunotherapy. The development of recombinant KLRG2 proteins has enabled researchers to investigate its structural properties, ligand interactions, and signaling pathways in greater detail. Studying the function of KLRG2, through its recombinant forms, aids in elucidating its role in immune tolerance and potential implications in diseases such as cancer and chronic infections. Furthermore, the use of recombinant proteins facilitates the exploration of KLRG2 as a therapeutic target, offering insights into how modulation of its activity could enhance immune responses. Overall, the investigation of KLRG2 and its recombinant variants is essential for advancing our understanding of immune regulation and developing innovative strategies for cancer immunotherapy and the treatment of infectious diseases.
