Analytical Data
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Gene name
HS6ST2
- Application
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Alternative Names
HS6ST2;Heparan-sulfate 6-O-sulfotransferase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MM7
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Expression Region
1-605aa
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AA Sequence
MALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRGVSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNMDEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKTGGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRNFHYITILRDPVSRYLSEWRHVQRGATWKASLHVCDGRPPTSEELPSCYTGDDWSGCPLKEFMDCPYNLANNRQVRMLSDLTLVGCYNLSVMPEKQRNKVLLESAKSNLKHMAFFGLTEFQRKTQYLFEKTFNMNFISPFTQYNTTRASSVEINEEIQKRIEGLNFLDMELYSYAKDLFLQRYQFMRQKEHQEARRKRQEQRKFLKGRLLQTHFQSQGQGQSQNPNQNQSQNPNPNANQNLTQNLMQNLTQSLSQKENRESPKQNSGKEQNDNTSNGTNDYIGSVEKWR
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Molecular Weight
69.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HS6ST2 (Heparan Sulfate 6-O-sulfotransferase 2) is an essential enzyme involved in the biosynthesis of heparan sulfate, a glycosaminoglycan crucial for various physiological processes, including cell signaling, migration, and differentiation. Research on HS6ST2 has gained momentum due to its potential implications in cancer biology, neurobiology, and developmental disorders. Elevated levels of HS6ST2 have been associated with tumor progression and metastasis, suggesting that it may act as an oncogene in certain contexts. Moreover, it plays a pivotal role in the regulation of morphogen gradients and cellular interactions during development. Understanding the functional mechanisms of HS6ST2 is vital for elucidating its contributions to disease states and may provide novel therapeutic targets. The recombinant expression of HS6ST2 allows for detailed biochemical characterization and investigation of its substrate specificity, enzymatic kinetics, and interaction with other proteins. This research not only enhances our fundamental understanding of glycosylation processes but also aids in the development of biomolecules that can manipulate heparan sulfate pathways for therapeutic applications, potentially leading to innovative treatments for cancer and genetic conditions linked to disrupted glycosaminoglycan metabolism.











