Analytical Data
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基因名
KCNK2
- Application
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别名
KCNK2；TREK；TREK1；Potassium channel subfamily K member 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95069
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表达区间
17.7 kDa
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氨基酸序列
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWD
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分子量
1-143aa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNK2, also known as TREK-1, is a member of the two-pore domain potassium (K2P) channel family, which plays a crucial role in maintaining the resting membrane potential and regulating neuronal excitability. Its ability to respond to various stimuli, including mechanical stretch, temperature changes, and chemical compounds, makes KCNK2 a significant focus in neuroscience and cardiovascular research. Dysfunction of KCNK2 has been linked to several pathological conditions, such as mood disorders, pain perception, and cardiac arrhythmias. Given its potential as a therapeutic target, the study of recombinant KCNK2 protein has garnered attention to better understand its functional mechanisms, physiological roles, and interactions with other cellular components. Researchers have employed various expression systems to produce recombinant KCNK2, facilitating the investigation of its biophysical properties and pharmacological profile. This approach aids in the development of novel drugs that can modulate KCNK2 activity, addressing unmet medical needs in neuropsychiatric complications and heart diseases while contributing to the broader field of ion channel research.
