Analytical Data
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基因名
DCTPP1
- Application
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别名
DCTPP1；XTP3TPA;dCTP pyrophosphatase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H773
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表达区间
1-170aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMSVAGGEIRGDTGGEDTAAPGRFSFS PEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTD GEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINR RRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCTPP1, or dCTP pyrophosphatase 1, is an essential enzyme involved in nucleotide metabolism, playing a crucial role in the regulation of cellular dCTP levels. Dysregulation of dCTP pools can significantly impact DNA synthesis and repair mechanisms, making DCTPP1 a key player in maintaining genomic stability. Recent studies have suggested that DCTPP1 may also be implicated in various diseases, including cancer, where altered nucleotide metabolism can promote tumorigenesis. Understanding the structure and function of DCTPP1 is vital for elucidating its biochemical pathways and potential therapeutic targets. Recombinant DCTPP1 proteins have become increasingly important in these studies, enabling researchers to explore enzyme kinetics, inhibition, and interaction with other cellular components. Moreover, the production of recombinant DCTPP1 facilitates high-throughput screening of small molecules that could serve as inhibitors or modulators of its activity, which may have therapeutic implications. As research continues to uncover the multifaceted roles of DCTPP1, the recombinant protein serves as a fundamental tool in advancing our understanding of nucleotide metabolism and its impact on cellular health and disease.
