Analytical Data
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基因名
DCTN2
- Application
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别名
DCTN2；DCTN50;Dynactin subunit 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13561
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表达区间
1-406aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMADPKYADLPGIARNEPDVYETSDLPE DDQAEFDAFAQELEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDR IGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKT TVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGA LAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAA KVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALD LAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPI ASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLT QVQTTMRENLATVEGNFASIDERMKKLGK
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCTN2, or Dynactin subunit 2, is a critical component of the dynactin complex, which plays a pivotal role in intracellular transport and mitosis by linking dynein motor proteins to their cargoes. Research on DCTN2 has gained attention due to its involvement in several cellular processes, including the regulation of cell division and the transport of organelles, vesicles, and protein complexes within neurons. Mutations or dysregulation of DCTN2 have been associated with various neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), underscoring its significance in maintaining neuronal integrity and function. The study of DCTN2 recombinant proteins allows for the exploration of its structural and functional properties, providing insights into its role in cellular mechanics and potential therapeutic avenues. By generating DCTN2 in a recombinant system, researchers can analyze its interactions with other cellular components and elucidate the molecular mechanisms underlying its involvement in disease pathology. This research is crucial, as it not only contributes to our understanding of neuronal transport processes but also aids in the development of targeted treatments to combat related neurodegenerative conditions. Thus, DCTN2 recombinant protein studies are an essential focus area in the realm of cellular and molecular biology, with significant implications for human health.
