Analytical Data
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Gene name
DCTN6
- Application
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Alternative Names
DCTN6；WS3;Dynactin subunit 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00399
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Expression Region
1-190aa
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AA Sequence
MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN
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Molecular Weight
47.7kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DCTN6 (Dynactin Subunit 6) is a crucial component of the dynactin complex, which plays a significant role in cellular transport and the regulation of intracellular processes, including mitosis and neuronal function. Research into DCTN6 has gained momentum due to its implication in various neurodegenerative diseases and its association with motor neuron disorders. Mutations or dysregulation of DCTN6 can disrupt the transport of cellular components, leading to cellular dysfunction and contributing to the pathogenesis of conditions such as ALS (Amyotrophic Lateral Sclerosis). The study of DCTN6 recombinant proteins has become vital for understanding its structure-function relationships, enabling the development of therapeutic strategies targeting dynactin-related pathways. By using recombinant DCTN6 proteins, researchers can dissect its role in cargo transport, interactions with microtubules, and the overall dynamics of the cellular cytoskeleton. Moreover, examining the effects of mutations on DCTN6 function within these proteins can provide insights into the molecular mechanisms underlying neurodegenerative diseases, thus fostering the development of potential interventions aimed at restoring normal cellular transport mechanisms. Overall, the investigation of DCTN6 recombinant proteins is enhancing our comprehension of its biological significance and opening avenues for novel therapeutic approaches in treating related disorders.
