Analytical Data
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Gene name
BANF1
- Application
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Alternative Names
BANF1；BAF；BCRG1；Barrier-to-autointegration factor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75531
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Expression Region
1-89aa
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AA Sequence
MTTSQKHRDF VAEPMGEKPV GSLAGIGEVL GKKLEERGFD KAYVVLGQFL VLKKDEDLFR EWLKDTCGAN AKQSRDCFGC LREWCDAFL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BANF1, or barrier-to-autointegration factor 1, is a key protein involved in the regulation of various cellular processes, including chromatin structure maintenance and the modulation of gene expression. It plays a crucial role in the nuclear architecture by facilitating the integration of viral genomes into the host cell’s chromatin and is essential for maintaining cellular integrity during mitosis. Research has shown that BANF1 is involved in DNA repair mechanisms and may have implications in cancer biology, particularly in tumorigenesis and the response to chemotherapy. Its ability to interact with several cellular partners highlights its significance in nuclear functions and cellular stress responses. Recent studies focusing on recombinant BANF1 protein are aimed at unraveling its structural characteristics and biochemical properties, which could enhance our understanding of its multifaceted roles within the cell. This research is pivotal as it opens avenues for targeting BANF1 in therapeutic strategies, particularly in cancers where its expression is dysregulated. Understanding the functional dynamics of BANF1 through its recombinant form can potentially lead to novel insights into cellular pathways and new strategies for cancer treatment. Thus, the investigation of BANF1 and its recombinant protein holds significant promise for advancing our knowledge of cell biology and developing innovative therapeutic approaches.
