Analytical Data
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Gene name
DCPS
- Application
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Alternative Names
DCPS；DCS1；HINT5;m7GpppX diphosphatase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96C86
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Expression Region
1-337aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMADAAPQLGKRKRELDVEEAHAASTEE KEAGVGNGTCAPVRLPFSGFR LQKVLRESARDKIIFLHGKVNEASGDG DGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQ LNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSI QWVYNILDKKAEADRIVFENPDPSD GFVLIPDLKWNQQQLDDLYLIAI CHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLP SY YHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTF ALRADDPLLKLLQEAQQS
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCPS (decapping scavenger enzyme) is a key player in RNA metabolism, particularly in the regulation of mRNA decay and turnover. Recent studies have highlighted the significance of DCPS in cellular processes, as it catalyzes the decapping of mRNA, thereby facilitating its degradation and playing a crucial role in gene expression control. The understanding of DCPS structure and function has advanced through biochemical and structural biology techniques, revealing its interactions with various co-factors and substrates. Given the central role of this enzyme in RNA regulation, research on DCPS has gained momentum, aiming to elucidate its mechanism of action, its regulatory pathways, and its potential implications in disease states, such as cancer and neurodegeneration, where mRNA dysregulation is often observed. By exploring the molecular intricacies of DCPS and its involvement in the cellular RNA landscape, researchers are seeking to uncover novel therapeutic targets and strategies for addressing disorders linked to RNA metabolism. This growing body of evidence positions DCPS as a critical focus for understanding broader cellular functions and developing innovative treatments.
